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If extended opioid use is needed in a pregnant lady, advise the affected person of the potential risk of neonatal opioid withdrawal syndrome and be certain that correct remedy will probably be readily available. (5.three)DILAUDID INJECTION is contraindicated in sufferers with recognized or suspected gastrointestinal obstruction, together with paralytic ileus.
Hydromorphone injection is utilised as a brief-phrase treatment To ease significant, acute pain (pain that begins instantly, has a selected trigger, and is anticipated to disappear when the cause of the pain is healed) in people who are expected to wish an opioid pain medication and who can not be controlled because of the use of different pain medicines.
Watch infants subjected to DILAUDID INJECTION through breast milk for excess sedation and respiratory despair. Withdrawal symptoms can happen in breastfed infants when maternal administration of hydromorphone is stopped, or when breast-feeding is stopped.
The pharmacokinetics of hydromorphone in sufferers with intense hepatic impairment has not been analyzed. An additional boost in Cmax and AUC of hydromorphone in this group is expected and should be taken into account when selecting a starting off dose [see Medical Pharmacology (12.3].
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Hydromorphone injection is in a class of prescription drugs named opiate (narcotic) analgesics. It works by changing just how the brain and anxious procedure reply to pain.
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The next adverse reactions associated with the usage of hydromorphone ended up discovered in scientific experiments or postmarketing experiences.
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Titrate the dosage of DILAUDID INJECTION slowly but surely in geriatric sufferers and watch carefully for indications of central nervous technique and respiratory melancholy [see Warnings and Safety measures (5.5)]. Hydromorphone is thought to generally be significantly excreted from the kidney, and the chance of adverse reactions to this drug may very well be better in people with impaired renal function. Simply because elderly sufferers usually tend to have diminished renal functionality, treatment really should be taken in dose choice, and it may be beneficial to watch renal operate.
Notify people that opioids could cause a rare but probably life-threatening situation termed serotonin syndrome resulting from concomitant administration of serotonergic medicines. Warn people from the signs or symptoms of serotonin syndrome and to seek healthcare notice without delay if signs establish right after discharge from check here medical center.
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